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TSI's Promilin® is a patented complex of bioactive amino acids including the extraordinary amino acid derivative, 4-hydroxyisoleucine (4-OH-Ile).
Derived from Trigonella foenum-graecum utilizing proprietary processing techniques at its own botanical extraction facility, Promilin shows remarkable promise in the areas of sports nutrition, weight management and glucose/insulin management.
Scientific studies in France, both in vitro and in vivo, have shown the 4-OH-Ile compound, found in Promilin, to be effective in selectively potentiating insulin secretion from the pancreas in response to an increase in glucose levels, and consequently have suggested it may increase insulin sensitivity1,2,3.
TSI has conducted bioactivity testing on Promilin utilizing pancreatic beta cells isolated from non-diabetes-prone Syrian hamsters, with the assistance of the University of Montana Department of Pharmaceutical Sciences. Results of its work have been consistent with the published European research and demonstrate that Promilin stimulates insulin secretion across a wide range of concentrations. Even more promising, in TSI's own pilot studies with healthy (non-diabetic) individuals, Promilin has actually been shown to help reduce glucose concentrations without affecting insulin levels, indicating that it may be enhancing natural metabolic sensitivity.
TSI is sponsoring a handful of clinical studies to further understand and validate benefit claims surrounding glucose transport / glycogen re-synthesis, weight management, and glucose metabolism in healthy, as well as, individuals with impaired glucose tolerance (IGT).
Promilin demonstrates TSI's commitment to developing and producing groundbreaking ingredients to provide our manufacturing partners a significant advantage in bringing sound, efficacious products to market.
For more information about purchasing products featuring Promilin, please click here Swanson Health Products
References:
1 Broca C, Manteghetti M, Gross R, Baissac Y, Jacob M, Petit P, Sauvaire Y, Ribes G., 4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion Eur J Pharmacol 2000 Mar 3;390(3):339-452.
2 Broca C, Gross R, Petit P, Sauvaire Y, Manteghetti M, Tournier M, Masiello P, Gomis R, Ribes G., 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties Am J Physiol 1999 Oct;277(4 Pt 1):E617-233.
3 Sauvaire Y, Petit P, Broca C, Manteghetti M, Baissac Y, Fernandez-Alvarez J, Gross R, Roye M, Leconte A, Gomis R, Ribes G., 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion Diabetes 1998 Feb;47(2):206-10.
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